On January 8th, 2000, the Tennessee Titans were essentially dead in the water, being down by one with under 20 seconds left in a playoff game against the Buffalo Bills.
Then TE Frank Wycheck threw a lateral (or forward pass, depending on how you view it) to Kevin Dyson, who took it to the house for what is known now as the Music City Miracle.
That one play set the entire Buffalo franchise back for years to come as they wouldn’t qualify and play in the postseason until 2018.